Codeine is indicated in patients older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol or ibuprofen (alone) Dry or painful cough Diarrhoea Adults: Codeine should be used at the lowest effective dose for the shortest period of time. The dose may be taken, up to 4 times a day at intervals of not less than 6 hours. Maximum daily dose of codeine should not exceed 240mg. The duration of treatment should be limited to 3 days and if no effective pain relief is achieved the patients/carers should be advised to seek the views of a physician. Paediatric population: Children aged 12 years to 18 years: The recommended codeine dose for children 12 years and older should be 30-60mg every 6 hours when necessary up to a maximum dose of codeine of 240mg daily. The dose is based on the body weight (0.5-1mg/kg). Children aged less than 12 years: Codeine should not be used in children below the age of 12 years because of the risk of opioid toxicity due to the variable and unpredictable metabolism of codeine to morphine (see section 4.3 and 4.4). Elderly: Dosage should be reduced in elderly patients. For dry or painful cough Adults: 15-30mg 3-4 times daily. Paediatric Population: Children aged less than 12 years: Codeine is contraindicated in children below the age of 12 years for the symptomatic treatment of cough see section 4.3. Children aged 12 years to 18 years Codeine is not recommended for use in children aged 12 years to 18 years with compromised respiratory function for the symptomatic treatment of cough (see section 4.4). Elderly: Dosage should be reduced in elderly patients Diarrhoea Adults: 30mg three to four times daily (range 15-60mg) Children: Not recommended. Elderly: Dosage should be reduced in elderly patients.